Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. AD, a representative form of senile dementia, occurs ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...

Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of its most specialized branches, chaperone-mediated autophagy, or CMA, does not engulf ...

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, ...

Ohio's six-month freeze on new Medicaid home care and hospice providers is set to expire Nov. 14, raising concerns among disabled residents who face gaps when aides leave. South Dakota voters will ...

According to cellular biology researchers, human cells continuously use a self-cleaning process called autophagy to recycle ...

Ohio's six-month freeze on new Medicaid home care and hospice providers is set to expire Nov. 14, raising concerns among disabled residents who face gaps when aides leave. South Dakota voters will ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...