Cell cycle deregulation is a common feature of human cancer. Cancer cells frequently display unscheduled proliferation, genomic instability (increased DNA mutations and chromosomal aberrations) and ...

(A) shows a general model. In the absence of a bound substrate, Plk1 is inactive due to the intramolecular interactions. To bind Plk1, the substrate must be primed by another kinase like CDKs. Once ...

A new review argues that transcriptional CDK inhibitors, especially CDK9 blockers, could simultaneously target oncogenic ...

Cancer is the second leading cause of death in Germany. In the search for new therapeutic approaches that target the uncontrolled growth of tumor cells, a class of enzymes known as cyclin-dependent ...

The transcriptional cdks phosphorylate the carboxy-terminal domain of RNA polymerase II, facilitating efficient transcriptional initiation and elongation. Inhibition of these cdks primarily affects ...

Cancer is the second-leading cause of death in Germany. In the search for new therapeutic approaches that target the uncontrolled growth of tumor cells, a class of enzymes known as cyclin-dependent ...

CDKs are enzymes that regulate cell-cycle progression, but their biological influence extends well beyond cell division. They also participate in gene transcription, DNA-damage responses, DNA repair, ...

In a major advance for molecular biology and cancer research, scientists have uncovered the molecular mechanisms that control a key step during the activation of cyclin-dependent kinases (CDKs) – the ...

Cyclin-dependent kinases are a type of serine/threonine kinase which are activated by cyclins to drive the progress of the cell cycle. The cell cycle is a comprised of 4 stages, which are tightly ...